Across TCGA patient cohorts, TRIM77 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM77-associated genes across cancer lineages are Annexin-1, Caspase-7-cleavedD198, and Rab25. Each is linked with TRIM77 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM77-to-partner and partner-to-TRIM77 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM77→partner) and Y-score (partner→TRIM77) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.686	+3.189	.005	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.701	+2.584	.011	.011	3	1
UCEC	Rab25 →	-0.378	-3.000	.014	.036	2	1
UCEC	Tuberin →	+0.317	+3.179	.011	.010	2	1
UCEC	S6_pS240_S244 →	+0.448	+2.584	.017	.011	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

TRIM77 survival (RNA) · tumor vs normal (RNA) · all TRIM77 data types