TRIM74

Across TCGA patient cohorts, TRIM74 mutation is significantly associated with the RNA expression of many other genes, with 126 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TRIM74-associated genes across cancer lineages are RNU1-57P, RNU6-803P, and ELOCP35. Each is linked with TRIM74 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM74-to-partner and partner-to-TRIM74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-57P grouped by TRIM74-low versus TRIM74-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM74→partner) and Y-score (partner→TRIM74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU1-57P →	+0.845	+5.611	<.001	<.001	3	2
STAD	RNU6-803P →	+0.771	+4.646	<.001	.004	3	2
STAD	ELOCP35 →	+0.091	+5.226	<.001	.003	3	2
UCEC	RNA5SP405 →	+0.442	+3.997	<.001	.009	3	2
UCEC	RNU2-47P →	+0.189	+5.475	<.001	.001	3	2
UCEC	LINC01318 →	+0.097	+3.294	.008	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

RNU1-57P by TRIM74 expression — STAD

Explore this box plot interactively →