TRIM74

Across TCGA pan-cancer cohorts, TRIM74 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TRIM74 data layer compared with 5 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TRIM74 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRIM74 expression acts as an unfavorable survival marker, although some lineages such as CESC and BLCA show a favorable association.

CESC, BLCA, and LUAD are the cancer types where TRIM74 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.839	0.642	<.001	52	view →
BLCA	OS	Quartile	All	0.781	0.627	.002	41	view →
LUAD	OS	Quartile	All	0.878	0.738	<.001	39	view →
BRCA	OS	Median	III,IV	0.896	0.762	.001	35	view →
READ	OS	Tertile	III,IV	0.888	0.544	.001	34	view →
LGG	DFS	Median	All	0.656	0.812	<.001	31	view →
SKCM	OS	Quartile	All	0.596	0.347	<.001	31	view →
KIRC	DFS	Median	All	0.533	0.690	.001	29	view →
ESCA	OS	Median	IV	0.222	0.698	.006	24	view →
PRAD	DFS	Median	All	0.672	0.893	<.001	18	view →
THCA	DFS	Tertile	III,IV	0.790	0.951	.017	16	view →
ACC	OS	Quartile	II,III,IV	0.888	0.236	.011	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TRIM74–CESC (DFS)

Open the CESC breakdown →