TRIM72

Across TCGA pan-cancer cohorts, TRIM72 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TRIM72’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TRIM72 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIM72 is over-expressed in tumor, although a few such as KIRP and HNSC show the opposite, repressed pattern.

COAD, BRCA, and KIRP are the cancer types where TRIM72 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM72 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.766	<.001	8	view →
BRCA	Female	All	+0.340	<.001	4	view →
KIRP	Male	All	−0.041	.004	4	view →
LUSC	All	All	+0.285	.006	3	view →
LUAD	All	All	+0.133	.020	2	view →
LIHC	Male	II,III,IV	+0.040	.012	2	view →
HNSC	Male	IV	−1.711	.041	1	view →
STAD	All	All	+0.392	.043	1	view →
CHOL	Male	All	+0.158	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TRIM72–COAD

Open the COAD breakdown →