Across TCGA patient cohorts, TRIM69 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM69-associated genes across cancer lineages are FASN, Cyclin-B1, and GSK-3a-b_pS21_S9. Each is linked with TRIM69 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM69-to-partner and partner-to-TRIM69 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM69→partner) and Y-score (partner→TRIM69) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.490	+1.807	.002	.027	3	3
UCEC	Cyclin-B1 →	+0.708	+2.321	.002	.006	3	3
UCEC	GSK-3a-b_pS21_S9 →	+0.375	+3.169	.033	.018	3	2
UCEC	STAT3_pY705 →	-0.360	-2.690	<.001	.006	3	2
SKCM	ACC_pS79 →	+0.294	+2.321	.042	.035	2	2
UCEC	EGFR →	-0.206	-2.321	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

TRIM69 survival (RNA) · tumor vs normal (RNA) · all TRIM69 data types