Across TCGA pan-cancer cohorts, TRIM69 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TRIM69’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRIM69 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIM69 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.
HNSC, KIRC, and LUAD are the cancer types where TRIM69 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM69 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.