TRIM68

Across TCGA patient cohorts, TRIM68 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM68-associated genes across cancer lineages are FoxM1, mTOR_pS2448, and EGFR_pY1068. Each is linked with TRIM68 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM68-to-partner and partner-to-TRIM68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TRIM68-low versus TRIM68-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM68→partner) and Y-score (partner→TRIM68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.224	+1.584	.027	.036	3	2
UCEC	mTOR_pS2448 →	-0.146	-2.308	.012	.033	3	2
UCEC	EGFR_pY1068 →	-0.256	-2.502	.009	.002	3	1
UCEC	eIF4E →	+0.233	+3.472	.004	.002	3	1
UCEC	eIF4G →	+0.296	+2.321	.015	.034	3	1
UCEC	A-Raf_pS299 →	-0.136	-2.115	.003	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

FoxM1 by TRIM68 expression — UCEC

Explore this box plot interactively →