TRIM68

Across TCGA pan-cancer cohorts, TRIM68 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TRIM68’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRIM68 RNA is repressed in tumor relative to normal tissue. In most cancer types TRIM68 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and BRCA are the cancer types where TRIM68 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM68 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.727	<.001	12	view →
THCA	All	All	−0.420	<.001	9	view →
BRCA	All	III,IV	−0.915	<.001	6	view →
LIHC	Male	All	+0.730	<.001	6	view →
CHOL	All	All	+1.696	<.001	3	view →
COAD	Male	IV	+0.655	.025	3	view →
KICH	Male	IV	−1.026	.007	2	view →
PRAD	All	All	+0.824	<.001	2	view →
KICH	Female	III,IV	+0.779	.006	2	view →
UCEC	All	All	−0.746	<.001	2	view →
READ	All	III,IV	−0.089	.006	2	view →
BLCA	Female	III,IV	+0.841	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TRIM68–KIRC

Open the KIRC breakdown →