TRIM68

Across TCGA cell cohorts, TRIM68 mutation is significantly associated with the RNA expression of many other genes, with 229 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM68-associated genes across cancer lineages are GSTA3, OR51T1, and GSG1L2. Each is linked with TRIM68 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM68-to-partner and partner-to-TRIM68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTA3 grouped by TRIM68-low versus TRIM68-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM68→partner) and Y-score (partner→TRIM68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GSTA3 →	+0.037	+4.108	.007	.005	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1
LUNG_SCLC	OR10A3 →	+0.062	+5.029	<.001	.006	3	1
LARGE_INTESTINE	CENPM →	+0.855	+3.321	<.001	.003	3	1
LARGE_INTESTINE	CEP76 →	+0.763	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 229 associations by consensus.

GSTA3 by TRIM68 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →