TRIM67

Across TCGA patient cohorts, TRIM67 mutation is significantly associated with the RNA expression of many other genes, with 3,667 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM67-associated genes across cancer lineages are GFM2, OIP5, and ABHD5. Each is linked with TRIM67 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM67-to-partner and partner-to-TRIM67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFM2 grouped by TRIM67-low versus TRIM67-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM67→partner) and Y-score (partner→TRIM67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GFM2 →	+0.515	+2.589	<.001	<.001	3	4
UCEC	OIP5 →	+0.687	+1.758	<.001	<.001	3	4
UCEC	ABHD5 →	+0.590	+2.214	<.001	<.001	3	4
UCEC	TTI2 →	+0.475	+1.747	<.001	<.001	3	4
UCEC	IARS1 →	+0.462	+2.343	.001	<.001	3	4
UCEC	PRC1 →	+0.510	+1.660	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,667 associations by consensus.

GFM2 by TRIM67 expression — UCEC

Explore this box plot interactively →