TRIM67

Across TCGA pan-cancer cohorts, TRIM67 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TRIM67’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRIM67 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIM67 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

HNSC, LUAD, and LIHC are the cancer types where TRIM67 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM67 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.040	<.001	9	view →
LUAD	All	All	+0.113	<.001	6	view →
LIHC	Female	III,IV	+0.056	.001	5	view →
BRCA	All	II,III,IV	+0.120	.034	4	view →
LUSC	All	All	+0.078	<.001	4	view →
COAD	Female	All	−0.071	.010	3	view →
KIRC	Male	All	−0.063	<.001	3	view →
PRAD	All	All	+0.050	<.001	2	view →
BLCA	Female	IV	+0.046	.017	2	view →
KICH	Female	II,III,IV	−0.132	.022	1	view →
STAD	Male	II,III,IV	+0.055	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TRIM67–HNSC

Open the HNSC breakdown →