TRIM65

Across TCGA patient cohorts, TRIM65 mutation is significantly associated with the RNA expression of many other genes, with 371 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM65-associated genes across cancer lineages are SLC25A51P3, HTATSF1P1, and RANP7. Each is linked with TRIM65 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM65-to-partner and partner-to-TRIM65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A51P3 grouped by TRIM65-low versus TRIM65-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM65→partner) and Y-score (partner→TRIM65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	SLC25A51P3 →	+0.099	+5.355	<.001	.005	3	2
SKCM	HTATSF1P1 →	+0.099	+4.296	<.001	.008	3	2
COAD	RANP7 →	+0.122	+5.392	.008	.002	3	2
SKCM	ACTR3P3 →	+0.038	+4.594	<.001	.008	3	2
LIHC	RNU1-133P →	+0.297	+5.447	<.001	.005	3	2
SKCM	RNA5SP384 →	+0.226	+4.867	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 371 associations by consensus.

SLC25A51P3 by TRIM65 expression — LIHC

Explore this box plot interactively →