TRIM63

Across TCGA patient cohorts, TRIM63 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM63-associated genes across cancer lineages are 14-3-3_epsilon, JNK2, and c-Met_pY1235. Each is linked with TRIM63 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM63-to-partner and partner-to-TRIM63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_epsilon grouped by TRIM63-low versus TRIM63-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM63→partner) and Y-score (partner→TRIM63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_epsilon →	+0.102	+3.321	.049	.010	3	2
UCEC	JNK2 →	+0.282	+2.834	.006	.034	3	1
UCEC	c-Met_pY1235 →	+0.091	+3.321	.019	.010	3	1
UCEC	INPP4B →	-0.406	-3.000	.016	.036	2	1
UCEC	NF-kB-p65_pS536 →	-0.553	-2.990	.020	.036	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

14-3-3_epsilon by TRIM63 expression — UCEC

Explore this box plot interactively →