TRIM63

Across TCGA pan-cancer cohorts, TRIM63 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TRIM63’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRIM63 RNA is repressed in tumor relative to normal tissue. In most cancer types TRIM63 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, THCA, and LUAD are the cancer types where TRIM63 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM63 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−1.787	.006	8	view →
THCA	Female	All	+1.227	<.001	8	view →
LUAD	All	III,IV	−0.447	<.001	8	view →
BLCA	All	III,IV	−1.803	.006	7	view →
COAD	Male	All	−0.176	<.001	7	view →
UCEC	All	All	−1.130	<.001	6	view →
LUSC	All	II,III,IV	−0.543	<.001	6	view →
KICH	All	All	−0.501	<.001	6	view →
STAD	All	IV	−0.236	.004	4	view →
BRCA	Female	All	−0.214	.012	4	view →
PRAD	All	All	−0.340	.014	2	view →
KIRC	Male	All	−0.351	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TRIM63–HNSC

Open the HNSC breakdown →