TRIM63

Across TCGA cell cohorts, TRIM63 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,716 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TRIM63-associated GO terms across cancer lineages are NMDA glutamate receptor clustering, Positive regulation of glutamate secretion, neurotransmission, and Regulation of NMDA receptor activity. Each is linked with TRIM63 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRIM63-to-partner and partner-to-TRIM63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMDA glutamate receptor clustering grouped by TRIM63-low versus TRIM63-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM63→partner) and Y-score (partner→TRIM63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NMDA glutamate receptor clustering →	+1.269	+0.079	<.001	.001	3	5
SKIN	Positive regulation of glutamate secretion, neurotransmission →	+0.168	+3.187	<.001	<.001	3	5
SKIN	Regulation of NMDA receptor activity →	+1.156	+2.343	<.001	<.001	3	4
BLOOD_Leukemia	Phasic smooth muscle contraction →	+1.146	+0.392	<.001	.003	3	4
SKIN	Poly(A)+ mRNA export from nucleus →	-0.089	-2.170	.009	.009	3	4
SKIN	Regulation of cellular response to insulin stimulus →	+0.034	+1.807	.006	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,716 associations by consensus.

NMDA glutamate receptor clustering by TRIM63 expression — UPPER_AERODIGESTIVE_TRACT

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