TRIM62

Across TCGA patient cohorts, TRIM62 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM62-associated genes across cancer lineages are FASN, p62 Lck ligand, and EGFR_pY1068. Each is linked with TRIM62 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM62-to-partner and partner-to-TRIM62 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by TRIM62-low versus TRIM62-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM62→partner) and Y-score (partner→TRIM62) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.436	+2.459	.022	.020	3	2
UCEC	p62 Lck ligand →	+0.444	+2.469	.004	.010	3	2
UCEC	EGFR_pY1068 →	-0.296	-2.321	.014	.034	3	1
UCEC	STAT3_pY705 →	-0.434	-3.159	<.001	.019	3	1
UCEC	IGFBP2 →	-1.377	-3.459	<.001	.005	2	1
UCEC	MEK1 →	+0.586	+2.459	<.001	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FASN by TRIM62 expression — UCEC

Explore this box plot interactively →