TRIM61

Across TCGA cell cohorts, TRIM61 RNA expression is significantly associated with the go_rna of many other GO terms, with 708 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM61-associated GO terms across cancer lineages are Actin filament depolymerization, Cardiac muscle tissue regeneration, and Positive regulation of mitochondrial electron transport, NADH to ubiquinone. Each is linked with TRIM61 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM61-to-partner and partner-to-TRIM61 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by TRIM61-low versus TRIM61-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM61→partner) and Y-score (partner→TRIM61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Actin filament depolymerization →	+0.104	+0.728	.002	.004	3	4
OVARY	Cardiac muscle tissue regeneration →	-0.118	-0.398	.007	.007	3	4
SOFT_TISSUE	Positive regulation of mitochondrial electron transport, NADH to ubiquinone →	+0.090	+0.320	.001	.007	3	3
SOFT_TISSUE	Regulation of Cdc42 protein signal transduction →	+0.115	+0.341	.005	.004	3	3
BLOOD_Lymphoma	Regulation of ovarian follicle development →	+0.090	+0.892	.002	.003	3	3
BLOOD_Lymphoma	Muscle cell proliferation →	-0.055	-0.951	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 708 associations by consensus.

Actin filament depolymerization by TRIM61 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →