TRIM60

Across TCGA pan-cancer cohorts, TRIM60 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TRIM60 data layer compared with 13 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TRIM60 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM60 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

SCLC, LUSC, and COAD are the cancer types where TRIM60 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.247	0.617	.015	6	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →
COAD	OS	Median	III,IV	0.239	0.791	.014	6	view →
UCEC	DFS	Median	All	1.000	0.630	.028	6	view →
ACC	DFS	Median	All	0.140	0.666	.049	3	view →
SKCM	DFS	Median	All	0.879	0.728	.036	3	view →
PRAD	DFS	Median	All	0.560	0.935	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TRIM60–SCLC (DFS)

Open the SCLC breakdown →