TRIM6-TRIM34

Across TCGA pan-cancer cohorts, TRIM6-TRIM34 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TRIM6-TRIM34 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TRIM6-TRIM34 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM6-TRIM34 expression acts as an unfavorable survival marker.

CESC, UCEC, and COAD are the cancer types where TRIM6-TRIM34 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.092	0.543	.018	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	OS	Median	III,IV	0.168	0.692	.043	3	view →
SKCM	DFS	Median	All	0.085	0.209	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TRIM6-TRIM34–CESC (DFS)

Open the CESC breakdown →