Across TCGA patient cohorts, TRIM59 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,289 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TRIM59-associated proteins across cancer lineages are SMC2, SMC4, and GMPS. Each is linked with TRIM59 in more than 7 cancer types. Because this analysis shows association rather than direction, both TRIM59-to-partner and partner-to-TRIM59 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM59→partner) and Y-score (partner→TRIM59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC2 →	+0.597	+0.668	<.001	<.001	3	8
LSCC	SMC4 →	+0.537	+0.808	<.001	<.001	3	7
OV	GMPS →	+0.801	+1.103	<.001	<.001	3	7
LSCC	MCM5 →	+0.551	+0.613	<.001	<.001	3	7
BRCA	NCAPG →	+0.485	+0.528	<.001	<.001	3	7
OV	PLOD2 →	+0.697	+0.858	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,289 associations by consensus.

Exploration

TRIM59 survival (RNA) · tumor vs normal (RNA) · all TRIM59 data types