Across TCGA patient cohorts, TRIM59 mutation is significantly associated with the RNA expression of many other genes, with 944 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM59-associated genes across cancer lineages are DNAJA1P1, MIR4727, and RNU6ATAC30P. Each is linked with TRIM59 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM59-to-partner and partner-to-TRIM59 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM59→partner) and Y-score (partner→TRIM59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	DNAJA1P1 →	+0.054	+5.891	<.001	<.001	3	2
SKCM	MIR4727 →	+0.668	+4.680	<.001	.007	3	2
UCEC	RNU6ATAC30P →	+0.227	+1.780	.007	.004	3	2
UCEC	LINC02644 →	+0.081	+2.558	<.001	.002	3	2
SKCM	MIR4667 →	+0.308	+4.680	<.001	.007	3	2
BLCA	DNAJA1P2 →	+0.038	+3.193	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 944 associations by consensus.

Exploration

TRIM59 survival (RNA) · tumor vs normal (RNA) · all TRIM59 data types