TRIM58

Across TCGA patient cohorts, TRIM58 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,126 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TRIM58-associated proteins across cancer lineages are SERPING1, SERPINA7, and C2. Each is linked with TRIM58 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM58-to-partner and partner-to-TRIM58 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TRIM58 versus SERPING1 in CCRCC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM58→partner) and Y-score (partner→TRIM58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SERPING1 →	+0.680	+0.275	<.001	<.001	3	4
CCRCC	SERPINA7 →	+0.429	+0.214	.001	.008	3	3
CCRCC	C2 →	+0.551	+0.272	<.001	<.001	3	3
PDAC	CYP51A1 →	-0.360	-0.110	.005	.001	3	3
CCRCC	F13A1 →	+0.605	+0.295	<.001	.001	3	3
PDAC	A2M →	+0.628	+0.207	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,126 associations by consensus.

TRIM58 vs SERPING1 — CCRCC

Explore this scatter interactively →