TRIM58

Across TCGA pan-cancer cohorts, TRIM58 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TRIM58 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TRIM58 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM58 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

LUSC, KIRC, and COAD are the cancer types where TRIM58 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.320	0.461	<.001	109	view →
KIRC	OS	Median	All	0.903	0.843	.001	61	view →
COAD	DFS	Quartile	III,IV	0.383	0.727	<.001	55	view →
UCEC	DFS	Quartile	All	0.552	0.597	.001	44	view →
KIRP	DFS	Quartile	II,III,IV	0.168	0.549	.004	41	view →
BRCA	OS	Tertile	III,IV	0.933	0.791	.005	33	view →
BLCA	DFS	Tertile	All	0.233	0.503	.014	27	view →
ACC	OS	Tertile	III,IV	0.196	0.876	.005	17	view →
ESCA	DFS	Tertile	III,IV	0.414	0.227	.018	17	view →
UVM	DFS	Median	All	0.729	0.474	.021	12	view →
LIHC	DFS	Quartile	III,IV	0.701	0.278	.007	12	view →
LUAD	DFS	Tertile	IV	0.389	0.792	.027	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TRIM58–LUSC (DFS)

Open the LUSC breakdown →