TRIM58

Across TCGA patient cohorts, TRIM58 mutation is significantly associated with the RNA expression of many other genes, with 4,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM58-associated genes across cancer lineages are RNU6-781P, LPIN1, and RNU6-1318P. Each is linked with TRIM58 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM58-to-partner and partner-to-TRIM58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-781P grouped by TRIM58-low versus TRIM58-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM58→partner) and Y-score (partner→TRIM58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-781P →	+0.568	+5.540	<.001	.004	3	4
UCEC	LPIN1 →	+0.481	+2.431	<.001	.001	3	4
LUAD	RNU6-1318P →	+0.436	+2.082	<.001	.004	3	4
SKCM	CKS1B →	+0.377	+2.019	.002	<.001	3	3
UCEC	ZBTB8OS →	+0.344	+2.185	<.001	.001	3	3
UCEC	CENPH →	+0.686	+2.914	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,138 associations by consensus.

RNU6-781P by TRIM58 expression — BRCA

Explore this box plot interactively →