TRIM58

Across TCGA cell cohorts, TRIM58 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,839 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM58-associated GO terms across cancer lineages are Cardiac muscle cell action potential, Ribosomal large subunit biogenesis, and Ribose phosphate biosynthetic process. Each is linked with TRIM58 in more than 7 cancer types. Because this analysis shows association rather than direction, both TRIM58-to-partner and partner-to-TRIM58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cardiac muscle cell action potential grouped by TRIM58-low versus TRIM58-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM58→partner) and Y-score (partner→TRIM58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Cardiac muscle cell action potential →	-0.124	-2.091	<.001	<.001	3	8
BLOOD_Leukemia	Ribosomal large subunit biogenesis →	+0.062	+1.803	.001	<.001	3	7
OVARY	Ribose phosphate biosynthetic process →	+0.062	+1.656	<.001	<.001	3	6
BLOOD_Leukemia	Establishment of protein localization to vacuole →	+0.049	+1.559	<.001	.001	3	6
SKIN	Retrograde transport, endosome to Golgi →	+0.055	+1.956	<.001	<.001	2	7
URINARY_TRACT	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.084	+1.592	.004	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,839 associations by consensus.

Cardiac muscle cell action potential by TRIM58 expression — OVARY

Explore this box plot interactively →