TRIM56

Across TCGA patient cohorts, TRIM56 mutation is significantly associated with the RNA expression of many other genes, with 2,997 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM56-associated genes across cancer lineages are ZFYVE19, TAF9, and GPR119. Each is linked with TRIM56 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM56-to-partner and partner-to-TRIM56 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFYVE19 grouped by TRIM56-low versus TRIM56-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM56→partner) and Y-score (partner→TRIM56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZFYVE19 →	+0.362	+2.439	.001	.001	3	3
UCEC	TAF9 →	+0.540	+2.700	<.001	<.001	3	3
HNSC	GPR119 →	+0.133	+5.102	<.001	.001	3	3
SKCM	LINC01565 →	+0.024	+2.072	<.001	.006	3	3
SKCM	ATP5MFP1 →	+0.122	+2.425	<.001	.003	3	3
UCEC	DHFR →	+0.561	+2.169	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,997 associations by consensus.

ZFYVE19 by TRIM56 expression — UCEC

Explore this box plot interactively →