TRIM56

Across TCGA patient cohorts, TRIM56 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM56-associated genes across cancer lineages are Src, ATM, and MEK1. Each is linked with TRIM56 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM56-to-partner and partner-to-TRIM56 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src grouped by TRIM56-low versus TRIM56-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM56→partner) and Y-score (partner→TRIM56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Src →	-0.304	-3.000	.021	.036	3	3
UCEC	ATM →	-0.567	-2.794	<.001	.002	3	3
UCEC	MEK1 →	+0.441	+3.807	<.001	<.001	3	2
UCEC	DJ-1 →	+0.179	+2.713	.001	.003	3	2
COAD	INPP4B →	-0.476	-2.991	.014	.036	3	1
COAD	IRS1 →	-0.166	-2.991	.040	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Src by TRIM56 expression — SKCM

Explore this box plot interactively →