TRIM56

Across TCGA cell cohorts, TRIM56 mutation is significantly associated with the RNA expression of many other genes, with 170 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM56-associated genes across cancer lineages are OR8B4, GSC2, and CT47A6. Each is linked with TRIM56 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM56-to-partner and partner-to-TRIM56 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B4 grouped by TRIM56-low versus TRIM56-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM56→partner) and Y-score (partner→TRIM56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	2
LUNG_NSCLC_LUAD	GSC2 →	+0.058	+3.866	<.001	.006	3	2
LUNG_SCLC	CT47A6 →	+1.412	+5.614	<.001	<.001	3	2
PANCREAS	RESP18 →	+0.030	+4.614	<.001	.004	3	1
URINARY_TRACT	CCDC178 →	+0.040	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	AVP →	+0.039	+5.149	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 170 associations by consensus.

OR8B4 by TRIM56 expression — OESOPHAGUS

Explore this box plot interactively →