TRIM55

Across TCGA patient cohorts, TRIM55 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM55-associated genes across cancer lineages are eIF4E, IRS1, and Notch1. Each is linked with TRIM55 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM55-to-partner and partner-to-TRIM55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TRIM55-low versus TRIM55-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM55→partner) and Y-score (partner→TRIM55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.116	+1.584	.049	.009	3	2
SKCM	IRS1 →	+0.118	+1.754	.021	.047	3	2
UCEC	Notch1 →	+0.226	+3.331	<.001	.005	3	2
UCEC	PKC-b-II_pS660 →	-0.346	-3.000	.009	.036	3	2
SKCM	p21 →	-0.285	-1.304	.048	.028	3	1
SKCM	PREX1 →	-0.239	-1.857	.029	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

eIF4E by TRIM55 expression — SKCM

Explore this box plot interactively →