TRIM55

Across TCGA cell cohorts, TRIM55 mutation is significantly associated with the drug of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM55-associated genes across cancer lineages are KRAS (G12C) Inhibitor-12, 5-Fluorouracil, and BPTES. Each is linked with TRIM55 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM55-to-partner and partner-to-TRIM55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRAS (G12C) Inhibitor-12 grouped by TRIM55-low versus TRIM55-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM55→partner) and Y-score (partner→TRIM55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.568	+2.868	.015	.022	3	2
LARGE_INTESTINE	5-Fluorouracil →	+0.565	+2.991	.040	.018	3	1
LARGE_INTESTINE	BPTES →	+0.609	+2.871	<.001	.021	3	1
LARGE_INTESTINE	GSK2801 →	+0.321	+2.871	.033	.021	3	1
LARGE_INTESTINE	123829 →	+0.567	+2.871	.040	.021	3	1
LARGE_INTESTINE	Sabutoclax →	+0.432	+2.991	.031	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

KRAS (G12C) Inhibitor-12 by TRIM55 expression — LARGE_INTESTINE

Explore this box plot interactively →