Across TCGA pan-cancer cohorts, TRIM53AP Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TRIM53AP data layer compared with 12 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TRIM53AP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM53AP expression acts as an unfavorable survival marker.

ESCA, SARC, and LIHC are the cancer types where TRIM53AP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.164	0.702	.001	33	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LIHC	DFS	Median	All	0.014	0.543	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TRIM53AP tumor-vs-normal RNA expression · all TRIM53AP data types