TRIM51HP

Across TCGA pan-cancer cohorts, TRIM51HP Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRIM51HP data layer compared with 14 for mass-spec protein.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher TRIM51HP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM51HP expression acts as an unfavorable survival marker.

GBM, ESCA, and SKCM are the cancer types where TRIM51HP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.005	0.416	<.001	12	view →
ESCA	OS	Median	III,IV	0.102	0.574	<.001	12	view →
SKCM	OS	Median	All	0.479	0.784	.009	8	view →
LGG	OS	Median	All	0.255	0.799	.001	6	view →
LIHC	OS	Median	All	0.475	0.778	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRIM51HP–GBM (OS)

Open the GBM breakdown →