TRIM50

Across TCGA patient cohorts, TRIM50 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM50-associated genes across cancer lineages are Cyclin-B1, FOXO3a_pS318_S321, and Ku80. Each is linked with TRIM50 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM50-to-partner and partner-to-TRIM50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TRIM50-low versus TRIM50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM50→partner) and Y-score (partner→TRIM50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.731	+2.584	.005	.011	3	2
UCEC	FOXO3a_pS318_S321 →	-0.124	-2.312	.033	.034	3	1
UCEC	Ku80 →	+0.240	+2.817	.029	.036	3	1
UCEC	MEK1 →	+0.413	+3.459	.015	.005	3	1
UCEC	mTOR_pS2448 →	-0.201	-3.439	.003	.005	3	1
UCEC	Myosin-IIa_pS1943 →	+0.224	+2.598	.020	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Cyclin-B1 by TRIM50 expression — UCEC

Explore this box plot interactively →