TRIM50

Across TCGA pan-cancer cohorts, TRIM50 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TRIM50 data layer compared with 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TRIM50 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRIM50 expression acts as an unfavorable survival marker, although some lineages such as LUAD and ACC show a favorable association.

LUAD, ACC, and KIRP are the cancer types where TRIM50 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.844	0.735	<.001	77	view →
ACC	OS	Quartile	II,III,IV	0.781	0.304	<.001	75	view →
KIRP	DFS	Median	All	0.959	0.859	<.001	63	view →
STAD	DFS	Quartile	IV	0.090	0.655	<.001	48	view →
READ	DFS	Median	All	0.345	0.829	.002	30	view →
HNSC	DFS	Tertile	IV	0.743	0.559	.005	25	view →
UCEC	DFS	Tertile	All	0.870	0.926	.010	20	view →
SARC	OS	Quartile	All	0.857	0.667	.003	19	view →
LIHC	DFS	Quartile	III,IV	0.135	0.405	.002	18	view →
PRAD	DFS	Median	All	0.642	0.876	.001	18	view →
DLBC	DFS	Tertile	All	0.342	1.000	.013	17	view →
BRCA	OS	Tertile	IV	0.195	0.682	.011	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TRIM50–LUAD (DFS)

Open the LUAD breakdown →