TRIM50

Across TCGA cell cohorts, TRIM50 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TRIM50-associated genes across cancer lineages are SPIC, OR10A4, and OR1L6. Each is linked with TRIM50 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM50-to-partner and partner-to-TRIM50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPIC grouped by TRIM50-low versus TRIM50-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM50→partner) and Y-score (partner→TRIM50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SPIC →	+0.008	+4.222	<.001	.006	3	1
OVARY	OR10A4 →	+0.028	+4.095	<.001	.003	3	1
OVARY	OR1L6 →	+0.012	+4.222	<.001	.006	3	1
OVARY	OR1N2 →	+0.018	+3.700	<.001	.005	3	1
OVARY	TPPP2 →	+0.091	+3.657	<.001	.009	3	1
OVARY	OR10G4 →	+0.021	+4.339	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SPIC by TRIM50 expression — OVARY

Explore this box plot interactively →