TRIM49B

Across TCGA cell cohorts, TRIM49B mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM49B-associated genes across cancer lineages are MYH2, MYH8, and IRS4. Each is linked with TRIM49B in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM49B-to-partner and partner-to-TRIM49B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH2 grouped by TRIM49B-low versus TRIM49B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM49B→partner) and Y-score (partner→TRIM49B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYH2 →	+0.050	+2.994	.006	.006	3	1
LARGE_INTESTINE	MYH8 →	+0.070	+3.242	.002	.003	3	1
LARGE_INTESTINE	IRS4 →	+0.255	+3.518	.001	.001	3	1
LARGE_INTESTINE	MS4A6E →	+0.018	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PDILT →	+0.005	+3.700	<.001	.009	3	1
LARGE_INTESTINE	FAM71B →	+0.002	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MYH2 by TRIM49B expression — LARGE_INTESTINE

Explore this box plot interactively →