TRIM49

Across TCGA pan-cancer cohorts, TRIM49 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TRIM49 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRIM49 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM49 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and LIHC are the cancer types where TRIM49 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.102	0.751	<.001	48	view →
UCEC	DFS	Median	II,III,IV	1.000	0.439	.017	30	view →
LIHC	OS	Median	All	0.098	0.777	.002	9	view →
SCLC	OS	Median	All	0.192	0.660	.003	6	view →
LUAD	OS	Median	IV	0.153	0.714	.012	6	view →
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	3	view →
SKCM	DFS	Median	III,IV	0.217	0.652	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TRIM49–HNSC (OS)

Open the HNSC breakdown →