TRIM49

Across TCGA patient cohorts, TRIM49 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM49-associated genes across cancer lineages are Notch1, Smad4, and EGFR_pY1068. Each is linked with TRIM49 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM49-to-partner and partner-to-TRIM49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TRIM49-low versus TRIM49-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM49→partner) and Y-score (partner→TRIM49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.207	+3.179	<.001	.010	3	2
SKCM	Smad4 →	+0.141	+3.012	.012	.018	3	2
UCEC	EGFR_pY1068 →	-0.323	-2.115	.003	.019	3	1
UCEC	A-Raf_pS299 →	-0.181	-3.169	<.001	.019	3	1
UCEC	ERK2 →	+0.237	+2.115	.004	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.623	+2.807	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Notch1 by TRIM49 expression — UCEC

Explore this box plot interactively →