TRIM49

Across TCGA cell cohorts, TRIM49 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TRIM49-associated genes across cancer lineages are OR4D5, C1orf146, and TAAR5. Each is linked with TRIM49 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM49-to-partner and partner-to-TRIM49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4D5 grouped by TRIM49-low versus TRIM49-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM49→partner) and Y-score (partner→TRIM49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4D5 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	C1orf146 →	+0.019	+3.734	<.001	.006	3	1
LUNG_SCLC	TAAR5 →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	C5orf52 →	+0.041	+4.058	<.001	.007	3	1
LUNG_SCLC	OR6Y1 →	+0.004	+4.058	<.001	.007	3	1
LUNG_SCLC	NKX1-1 →	+0.073	+4.169	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR4D5 by TRIM49 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →