TRIM48

Across TCGA pan-cancer cohorts, TRIM48 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TRIM48 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TRIM48 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TRIM48 expression acts as an unfavorable survival marker, although some lineages such as LUSC and UCEC show a favorable association.

LUSC, UCS, and PRAD are the cancer types where TRIM48 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.787	0.362	.018	11	view →
UCS	OS	Median	All	0.185	0.686	.034	6	view →
PRAD	OS	Median	All	0.693	0.990	<.001	6	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	6	view →
UCEC	DFS	Median	All	0.929	0.604	.017	6	view →
SARC	DFS	Median	All	0.127	0.611	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TRIM48–LUSC (DFS)

Open the LUSC breakdown →