Across TCGA pan-cancer cohorts, TRIM48 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of TRIM48’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TRIM48 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIM48 is over-expressed in tumor.
LUSC are the cancer types where TRIM48 tumor–normal differential expression is most reproducible.