TRIM48

Across TCGA patient cohorts, TRIM48 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM48-associated genes across cancer lineages are STAT3_pY705, Cyclin-B1, and S6_pS240_S244. Each is linked with TRIM48 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM48-to-partner and partner-to-TRIM48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by TRIM48-low versus TRIM48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM48→partner) and Y-score (partner→TRIM48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.325	-1.459	<.001	.012	3	3
UCEC	Cyclin-B1 →	+0.569	+1.459	.001	.012	3	3
UCEC	S6_pS240_S244 →	+0.279	+1.887	.034	.029	3	2
UCEC	ATM →	-0.373	-1.459	.011	.012	3	2
UCEC	Collagen-VI →	-0.136	-3.446	.042	.005	3	2
UCEC	14-3-3_beta →	-0.080	-2.780	.014	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

STAT3_pY705 by TRIM48 expression — UCEC

Explore this box plot interactively →