TRIM48

Across TCGA cell cohorts, TRIM48 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible TRIM48-associated genes across cancer lineages are MAGEB5, GSX1, and RNF212B. Each is linked with TRIM48 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM48-to-partner and partner-to-TRIM48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by TRIM48-low versus TRIM48-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM48→partner) and Y-score (partner→TRIM48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_SCLC	GSX1 →	+0.627	+3.468	.004	.007	3	1
LARGE_INTESTINE	RNF212B →	+0.122	+3.678	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MAGEB5 by TRIM48 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →