TRIM46

Across TCGA pan-cancer cohorts, TRIM46 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TRIM46 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TRIM46 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM46 expression acts as an unfavorable survival marker.

LUAD and GBM are the cancer types where TRIM46 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.905	1.000	.018	7	view →
GBM	DFS	Median	All	0.214	0.400	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TRIM46–LUAD (DFS)

Open the LUAD breakdown →