TRIM46

Across TCGA pan-cancer cohorts, TRIM46 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TRIM46’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRIM46 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIM46 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where TRIM46 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM46 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.612	<.001	12	view →
COAD	Male	IV	+0.700	<.001	10	view →
LUAD	Female	All	+0.899	<.001	9	view →
KIRC	All	III,IV	+0.422	<.001	9	view →
LIHC	Female	II,III,IV	+0.225	<.001	9	view →
THCA	Male	All	+0.654	<.001	8	view →
KICH	Female	II,III,IV	−0.708	<.001	7	view →
BRCA	All	II,III,IV	+0.827	<.001	6	view →
STAD	All	II,III,IV	+0.560	<.001	6	view →
PAAD	All	All	+1.242	.005	4	view →
BLCA	All	All	+0.592	.018	4	view →
LUSC	All	All	+0.541	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TRIM46–HNSC

Open the HNSC breakdown →