TRIM46

Across TCGA patient cohorts, TRIM46 protein abundance is significantly associated with the RNA expression of many other genes, with 2,745 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TRIM46-associated genes across cancer lineages are WDR81, CTNS, and PRKG2. Each is linked with TRIM46 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM46-to-partner and partner-to-TRIM46 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TRIM46 versus WDR81 in LSCC, with a Pearson correlation of -0.89.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM46→partner) and Y-score (partner→TRIM46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR81 →	-0.851	-1.220	.007	.008	3	2
LSCC	CTNS →	-0.741	-1.343	.002	.001	3	2
LUAD	PRKG2 →	+0.782	+0.769	.001	.004	3	2
GBM	DIRAS2 →	+0.919	+0.210	<.001	.002	3	2
LUAD	CSRNP3 →	+1.036	+0.827	.001	.002	3	2
GBM	TAFA2 →	+0.650	+0.279	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,745 associations by consensus.

TRIM46 vs WDR81 — LSCC

Explore this scatter interactively →