TRIM46

Across TCGA cell cohorts, TRIM46 mutation is significantly associated with the RNA expression of many other genes, with 328 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM46-associated genes across cancer lineages are PRSS58, WRAP73, and LCT. Each is linked with TRIM46 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM46-to-partner and partner-to-TRIM46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by TRIM46-low versus TRIM46-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM46→partner) and Y-score (partner→TRIM46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	2
LARGE_INTESTINE	WRAP73 →	+0.502	+3.364	.008	.002	3	2
BLOOD_Leukemia	LCT →	+0.449	+3.279	.001	.008	3	2
SKIN	IFNA16 →	+0.138	+3.684	<.001	.006	3	1
SKIN	RBMY1F →	+0.052	+4.437	<.001	.004	3	1
SKIN	CLEC6A →	+0.071	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 328 associations by consensus.

PRSS58 by TRIM46 expression — PANCREAS

Explore this box plot interactively →