TRIM45

Across TCGA patient cohorts, TRIM45 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM45-associated genes across cancer lineages are MSH2, Caspase-7-cleavedD198, and S6_pS240_S244. Each is linked with TRIM45 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM45-to-partner and partner-to-TRIM45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by TRIM45-low versus TRIM45-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM45→partner) and Y-score (partner→TRIM45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.283	-2.575	.001	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.642	+1.874	.004	.049	3	2
COAD	S6_pS240_S244 →	+0.409	+3.025	.046	.019	3	1
UCEC	EGFR_pY1068 →	-0.191	-1.678	.047	.023	3	1
UCEC	EGFR →	-0.188	-2.459	.002	.019	3	1
UCEC	JNK2 →	+0.242	+2.087	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MSH2 by TRIM45 expression — UCEC

Explore this box plot interactively →