TRIM45

Across TCGA pan-cancer cohorts, TRIM45 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TRIM45 data layer compared with 6 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TRIM45 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRIM45 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUSC show a favorable association.

BRCA, ACC, and THCA are the cancer types where TRIM45 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.956	0.892	<.001	99	view →
ACC	OS	Tertile	All	0.339	0.884	<.001	91	view →
THCA	OS	Tertile	All	0.847	0.990	<.001	91	view →
DLBC	DFS	Median	All	0.644	0.945	.003	82	view →
LIHC	DFS	Median	All	0.447	0.634	<.001	74	view →
KICH	DFS	Tertile	III,IV	0.287	1.000	<.001	70	view →
KIRC	DFS	Median	II,III,IV	0.419	0.611	.001	58	view →
LGG	DFS	Median	All	0.625	0.849	<.001	54	view →
SKCM	OS	Tertile	II,III,IV	0.230	0.387	<.001	33	view →
LUSC	OS	Tertile	All	0.531	0.302	<.001	24	view →
STAD	OS	Median	III,IV	0.535	0.701	.013	22	view →
CHOL	DFS	Quartile	All	0.217	0.736	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TRIM45–BRCA (OS)

Open the BRCA breakdown →