TRIM45

Across TCGA cell cohorts, TRIM45 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM45-associated genes across cancer lineages are OOSP4A, MT4, and TKTL2. Each is linked with TRIM45 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM45-to-partner and partner-to-TRIM45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP4A grouped by TRIM45-low versus TRIM45-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM45→partner) and Y-score (partner→TRIM45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OOSP4A →	+0.093	+4.115	<.001	.001	3	2
LARGE_INTESTINE	MT4 →	+2.944	+3.556	<.001	.007	3	1
LARGE_INTESTINE	TKTL2 →	+0.059	+4.509	<.001	<.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1
LARGE_INTESTINE	PROKR1 →	+0.059	+3.725	<.001	.008	3	1
LARGE_INTESTINE	VWC2L →	+0.009	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

OOSP4A by TRIM45 expression — LARGE_INTESTINE

Explore this box plot interactively →